@article {20, title = {Design, simulation and application of a new micromixing device for time resolved infrared spectroscopy of chemical reactions in solution}, journal = {Lab on a Chip}, volume = {1}, year = {2001}, pages = {16{\textendash}21}, abstract = {

We present a novel micromachined fast diffusion based mixing unit for the study of rapid chemical reactions in solution with stopped-flow time resolved Fourier transform infrared spectroscopy (TR-FTIR). The presented approach is based on a chip for achieving lamination of two liquid sheets of 10 μm thickness and \~{}1 mm width on top of each other and operation in the stopped-flow mode. The microstructure is made on infrared transmitting calcium fluoride discs and built up with two epoxy negative photoresist layers and one silver layer in between. Due to the highly laminar flow conditions and the short residence time in the mixer there is hardly any mixing when the two liquid streamlines pass through the mixing unit, which allows one to record a mid-IR transmission spectrum of the analytes prior to reaction. When the flow is stopped, the reactant streams are arrested in the flow-cell and rapidly mixed by diffusion due to the reduced interstream distances and the reaction can be directly followed with hardly any dead time. On the basis of two model reactions{\textemdash}neutralisation of acetic acid with sodium hydroxide as well as saponification of methyl monochloroacetate{\textemdash}the performance of the mixing device was tested revealing proper functioning of the device with a time for complete mixing of less than 100 ms. The experimental results were supported by numerical simulations using computational fluid dynamics (CFD), which allowed a reliable, quantitative analysis of concentration, pressure and flow profiles in the course of the mixing process.

}, doi = {http://dx.doi.org/10.1039/b104391a}, author = {Hinsmann, Peter and Frank, Johannes and Svasek, Peter and Harasek, Michael and Lendl, Bernhard} }